The average dose rate compares favorably to the published literature.įLASH therapy (irradiations >100 Gy/s) promises to selectively spare healthy tissue. In conclusion, FLASH plans were designed and evaluated in the TPS with dose rate and scanning speed achievable by an IBA Proteus system leading to dose delivery timing compatible with published FLASH conditions. The resulting plans are compared to published results. Using the spot delivery simulator and FLASH dedicated scorers implemented in the RayStation Monte Carlo dose engine, we evaluate and display FLASH metrics derived from voxel wise energy deposition time traces (0.1 ms resolution) such a dose rate vs. The delivery was in PBS mode using a SOBP modulated with a ridge filter and a range compensator for lateral modulation. Treatment plans for FLASH delivery were generated by interfacing a research version of the RayStation TPS (RaySearch Laboratories AB) with a software simulator of the IBA Proteus system (IBA S.A.). This high dose rate implies that the TPS must take into account the timing of spot delivery during plan design and evaluation. Flash irradiation involves irradiating tissue at high dose rate (typically above 40 Gy/s) in order to spare healthy tissue.
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